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Name: Savannah Momo
Location: Nanjing, FL
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The useful of Anthrone

Posted by Savannah Momo on Tuesday, December 22, 2009 2:16:21 AM

Molecular formula: C14H10O Molecular weight: 194.23 Properties: colorless needle-like crystals. Melting point 156 ?. Soluble in acetone, benzene, most organic solvents, does not produce fluorescence, slightly soluble in water. Do not dissolve in cold caustic soda solution, when heated formed anthralin dissolved alkali metal salts. Colorless needle-like crystals.

Uses: Determination of body fluids, sugar, starch, animal liver tissue. Organic synthesis, for the preparation of benzo-Anthrone  and dyes, but also for the colorimetric determination of carbohydrates. By the anthraquinone with tin and hydrochloric acid or sodium hydrosulfite to restore the system.

 

Description: Anthrone                      
Synonym: 9 (10H) - Anthracenone
CAS No.: 90-44-8
Assay: ≥ 95%(HPLC)
Appearance: slight yellow or off-white crystalline powder
Molecular: C14H10O

 

from:timepharm

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Chinese pharmaceutical intermediates market

Posted by Savannah Momo on Wednesday, December 16, 2009 1:04:54 AM

Expert opinion 2: Select Advantage Variety

China's pharmaceutical intermediates product chain upper, middle and upper reaches of the basic raw material drug intermediates due to wider application areas, accounting for the entire chain of dominant position, it has been more rapid development, but also on the market came under scrutiny. However, China's exports of pharmaceutical intermediates have also been pressure from other countries, especially India. India's rapid rise in pharmaceutical industries, and now with our form of competition and symbiotic relationship.
 
Facts have proved that pharmaceutical intermediates in China, a major exporter of the European Union, North America, the Middle East, Southeast Asia, from India, the impact can not be overlooked. As a result, China's export of pharmaceutical intermediates sector need to adjust strategy. Experts believe that a competitive selection intermediate species or will be an effective breakthrough. Specific varieties of view, sulfonamides, tetracyclines, analgin and other commodities is going out early varieties.
 
Over time, the rapid development of China's pharmaceutical intermediates, from the current accounts for some varieties of visible share of the world's leading production and marketing to our advantage. Such as VC, penicillin, for acetyl amino phenol, paracetamol, citric acid and other accounts for more than 60% of the share of the world, amoxicillin, ceftriaxone, ibuprofen, aspirin, etc. are influential in the global product range . In the product category, the anti-infectives, vitamins, antipyretic and analgesic, amino acids and other raw material medicine of China's export-oriented series, the total raw material medicine for more than 90% of total exports, and the corresponding intermediates of domestic demand is also greater.
 
The experts also advise the relevant Pharmaceutical Intermediates manufacturers enterprises: As the situation goes on, research and production of pharmaceutical intermediates have to be adjusted. Experts believe that the changes in disease spectrum will create new areas of pharmaceutical market, the corresponding pharmaceutical intermediates also change, so has brought new opportunities. The seminar, the experts have speculated that: in 2010 the highest incidence of the disease with mental illness, menopause, disease, erectile dysfunction, obesity, cardiovascular and cerebrovascular diseases, cancer, chronic sinusitis, migraine headaches, diabetes, age-related diseases, fatal infections, which will usher in increased demand related to drug intermediates.

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Important chloroformate esters include 4-nitrophenyl chloroformate

Posted by Savannah Momo on Thursday, December 10, 2009 10:46:08 PM

Chloroformic acid is an unstable chemical compound with the formula ClCO2H. It is the single acyl-halide derivative of carbonic acid (phosgene is the double acyl-halide derivative). Chloroformic acid is also structurally related to formic acid, which has a hydrogen instead of the chlorine.

Chloroformic acid itself is too unstable to be handled for chemical reactions. However, many esters of this carboxylic acid are stable and these chloroformates are important reagents in organic chemistry. They are used to prepare mixed carboxylic acid anhydrides used in peptide synthesis. Like other related halocarbons, it is a potentially dangerous alkylating agent.

Important chloroformate esters include 4-nitrophenyl chloroformate , fluorenylmethyloxycarbonylchloride, benzyl chloroformate and ethyl chloroformate.

Synonym: Chloroformic Acid 4-Nitrophenyl Ester
CAS: 7693-46-1
Assay: ≥96% (GC) ,98%(Titration)
Appearance: white or off-white crystal
Molecular: ClCO2C6H4NO2
 

 

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4-Nitrophenyl Chloroformate impact on the environment

Posted by Savannah Momo on Tuesday, December 08, 2009 3:21:33 AM

Description: 4-Nitrophenyl Chloroformate GC 96% or 4-Nitrophenyl Chloroformate Titration 98%
Synonym: Chloroformic Acid 4-Nitrophenyl Ester
CAS: 7693-46-1
Assay: ≥96% (GC) ,98%(Titration)
Appearance: white or off-white crystal
Molecular: ClCO2C6H4NO2
Application: Anti-HIV as Pharmaceutical Intermediates
 
 
Health hazard: the mucous membrane and skin stimulation, causing methemoglobinemia.
 
Acute poisoning: Patients may have headache, dizziness, fatigue, skin and mucous membrane cyanosis, finger numbness and other symptoms. In severe cases, there may be chest tightness, shortness of breath, palpitations and even heart rhythm disorders, coma, convulsions, respiratory paralysis. And sometimes can cause hemolytic anemia, liver damage.
 
Chronic poisoning: in headache, fatigue, insomnia, memory loss and other neurological wasting syndrome; a chronic hemolysis, they can include jaundice, anemia; can cause toxic hepatitis.
 
Two, toxicology information and environmental behavior toxicity: it is highly toxic. Acute toxicity: LD50420mg/kg (rat oral); 16000mg/kg (free percutaneous) hazardous characteristics: case of fire, combustible high fever. Reactions can occur with strong oxidants. Subject to heat decomposition, produce toxic gases of nitrogen oxides and chlorides. Corrosive. Combustion (decomposition) products: carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride.
 
3. Emergency Monitoring Methods: direct inlet gas chromatography
 
4. Laboratory monitoring methods: gas chromatography (GB13194-91, Water), naphthyl ethylenediamine hydrochloride colorimetry, "Determination of harmful substances in the air" (second edition), Hang Shi-ping editor
 
5. environmental standards: China (TJ36-79) workshop in the air of harmful substances maximum allowable concentration 1mg/m3 [Paper] the former East Germany (1977) air quality standards 0.04mg/m3 China (to be issued) to drink with source water of harmful substances maximum allowable concentration of 0.05mg / L of China (GB8978-1996) Integrated Wastewater Discharge Standard 1 0.5mg / L 2 1.0mg / L 3 5.0mg / L
 
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the phenolysis of bis(4-nitrophenyl) carbonate

Posted by Savannah Momo on Thursday, December 03, 2009 1:11:06 AM

The reactions of a homogeneous series of phenols with bis(4-nitrophenyl) carbonate (BNPC), bis(4-nitrophenyl) thionocarbonate (BNPTOC), and methyl 4-nitrophenyl thionocarbonate (MNPTOC) are subjected to a kinetic investigation in water, at 25.0 degrees C and ionic strength of 0.2 M (KCl). Under excess of phenol over the substrate, all the reactions obey pseudo-first-order kinetics and are first order in phenoxide anion.

 

The reactions of BNPC show a linear Brönsted-type plot with slope beta = 0.66, consistent with a concerted mechanism (one step). In contrast, those of BNPTOC and MNPTOC show biphasic Brönsted-type plots with slopes beta = 0.30 and 0.44, respectively, at high pK(a), and beta = 1.25 and 1.60, respectively, at low pK(a), consistent with stepwise mechanisms. For the reactions of both thionocarbonates, the pK(a) value at the center of the Brönsted plot (pK(a)(0)) is 7.1, which corresponds to the pK(a) of 4-nitrophenol. This confirms that the phenolyses of the thionocarbonates are stepwise processes, with the formation of an anionic tetrahedral intermediate. By the comparison of the kinetics and mechanisms of the title reactions with similar reactions, the following conclusions can be drawn:

(i) Substitution of S(-) by O(-) in an anionic tetrahedral intermediate (T(-)) destabilizes it.

(ii) The change of MeO by 4-nitrophenoxy in T(-) results in an increase of both the rate constant and equilibrium constant, for the formation of T(-), and also in an enlargement of the rate coefficient for the expulsion of 4-nitrophenoxide from T(-).

(iii) Substitution of an amino group in a tetrahedral intermediate by ArO destabilizes it.

(iv) Secondary alicyclic amines and other amines show greater reactivity toward MNPTOC than isobasic phenoxide anions.

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FIGHT FOR HEALTH, THINKING GOES FIRST

Posted by Savannah Momo on Monday, November 23, 2009 9:45:21 PM

FIGHT FOR HEALTH, THINKING GOES FIRST

FIGHT FOR HEALTH, THINKING GOES FIRST
Everyday, when we open the television, countless of drug advertisings for “affluenza” begin to flood our eyes. Many people feel disgust to the advertisings and scared the disease, because they know that such a lot people nearing are suffering with this disease but could not do anything about it. It just like a child lost in the forest that does not know which path could lead him out.

In my mind, difficult things are as enemies on the battlefield. The most you want to beat them, the first you have do, is to have a detailed recognition to them, then you could choose a way to “get rid of them”.

First of all, we must to know what is hyperlipemia? The reason to cause it and the result it will cause. Human body is a modern metropolis, dominated by intricate and complicated transport lines – the blood vessel – each moment. Because the body used them to transport oxygen and nutritive materials to different organs, and to transport CO2 and some “trash” out. It is well known that nourishment, such as cholesterol and vitamin D, are necessary and useful for our body and brain, but this does not mean the more we take in, the smarter and healthier we will be. Things always have two sides that opposite to each other, and right will turn to wrong if it is done too much to brake the line. nourishment are these things which were called “wealthy food ”. If they are took in but not completely ingested by your body, the superfluous will stay and accumulate on your inner artery wall to form plaque . LDL (low-density lipoprotein) are believed the worst aliment when it was take in excess. It will adhere on the inner artery wall and accumulate. The artery will be blocked if the acumulated LDL is too much, and bad things will come. For example, If an obstruction occurs in the coronary arteries, it could result in a heart attack. And, if an obstruction occurs in the arteries of the brain, it could lead to stroke.

Two ways could be chose for reducing the LDL’s percentage in the body. First and main way is to take in food with smaller fat or small fat food to reduce fat’s quantity; the other is use something (always drugs) to consume the superfluous fat (include LDL). We all believe believe the most useful method is to form a good diet habit, but an effective drug used in auxiliary can not only relieve the the patient’s pain, but also give the courage to beat hyperlipemia.

Lipid-lowering drugs mainly include statins, fibrates, nicotinic acid and bile acid sequestrants. They have functions on different kind of fat, but the purpose is same – to reduce the fat. For example, fibrates are more active in reducing triglyceride than reducing cholesterol, while HMG-Co A (3-hydroxy-3-methylglutary coenzyme A) are main active on reducing cholesterol with high effects. Recently, a compound medicine of Ezetimibe was released to used as reducing cholesterol drug. (It is honored that one of our product — 2-Chloro-4,6-dimethoxy-1,3,5-triazine — could be used as one of its intermediates. A research from Britain indicates that this drug has higher effects on reducing cholesterol than others.

Progress in culture and technology let us pay closer attention to health. We want to fight for health along with all Pharmaceutical  Intermediates corporates to make life more beautiful and colorful.
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Time-chem & The Global Economy

Posted by Savannah Momo on Monday, November 23, 2009 9:42:33 PM
Time-chem & The Global Economy

China is leading the way forward as global trade rebounds. China’s GDP is estimated to have risen by a seasonally adjusted annual rate of 14% in the second quarter, OECD says. “The economic stimulus package implemented by the Chinese government has had a clear and positive impact on the national economy, and it is already evident that both demand and pricing of petroleum and petrochemical products are recovering,” Sinopec said late last month. The global petchem sector needs recovery to continue as Sinopec and joint venture partners are set to increase ethylene capacity by nearly 3 million m.t./year through next year, with plants at Fujian and Tianjin coming onstream in the second half, and another unit at Ningbo starting up in 2010.
Spring may be arriving about six months late for the global economy and chemical makers. Late summer economic news has been mostly favorable, and indicators point to continued improvement in demand. Inventory depletion is no longer dragging down demand, and restocking could provide some lift in late 2009.Time-chem will continue to work hard,, our Pharmaceutical Intermediates products, Electronic Chemicals products and Fine Chemicals products will give clients high quality ones, we will provide our best products and services to better display Time-Chem.

http://www.blogigo.com/timephram
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